Best Sleep Supplements in 2026: Ranked by What the Trials Found

Editorial Note: This article was produced by the Veluna Sleep Editorial Team. Where research is cited, we link to peer-reviewed sources such as PubMed and NIH.

Research linked here relates to individual ingredients and does not establish that the finished Veluna product has been clinically studied or will produce the same results.

By Veluna Sleep Editorial Team · Updated October 1, 2026 · 14 min read

Key Takeaways

✓ There is no single best herbal sleep aid. Valerian has the most trials and the least consistent results, passionflower and chamomile each have a small number of positive trials, and melatonin, which is a hormone rather than a herb, has the largest evidence base with modest average effects.

✓ Combining herbs does not automatically add up. A 2024 placebo-controlled trial of a four-ingredient blend found no benefit beyond placebo, while a valerian-hops combination produced modest effects in two trials. Judge a blend by its stated amounts, not by the length of its ingredient list.

✓ A proprietary blend hides the one thing you need. Under FDA labelling rules a proprietary blend must list its total weight and its ingredients in descending order, but not the amount of each one, so you cannot compare it with what the trials used.

✓ Decide on melatonin first, then on format. Blends that include melatonin carry extra cautions for pregnancy, nursing, people under 18 and anyone on medication; herb-only blends carry the cautions of their herbs.

The best sleep supplements, ranked by what the trials found

This ranking uses the controlled trials summarised further down this page, the amounts those trials used, and how honestly each ingredient is usually labelled. None of these is strong in the way a prescription medicine is strong; the ones that are strong are prescription medicines. Research described here relates to individual ingredients, not to any finished Veluna product.

  1. Low-dose melatonin. The largest evidence base of anything on this list, with modest and consistent effects: about 4 minutes sooner to sleep and about 13 minutes more sleep across 17 studies (PMID: 15649737). Its real strength is timing, for jet lag and a delayed sleep-wake phase (NCCIH). Keep the amount low: in our count of the NIH supplement label database, 890 of 2,674 melatonin labels sit at 3 mg, 922 at 5 mg or more, and only 596 at 1 mg or under, while the amounts used in research start well below 1 mg.
  2. Magnesium (glycinate form). Three small trials in older adults found time to fall asleep shortened by an average of seventeen minutes, with the evidence rated low quality (PMID: 33865376). The most useful single ingredient for someone who wants an evening routine without a hormone.
  3. Valerian root. The most studied herb and the least consistent. Subjective sleep quality improved across 10 pooled studies with no severe adverse events (PMID: 33086877), while objective measures did not move (PMID: 38359657). Good safety record at 300 to 600 mg a day for up to 6 weeks (NCCIH).
  4. Chamomile. Improved a sleep-quality score in pooled trials (PMID: 39106912); the extract amounts used were around 540 mg a day, far more than a tea bag delivers.
  5. Passionflower. Raised total sleep time in one two-week trial; otherwise a small evidence base. Not in pregnancy or near surgery (NCCIH).
  6. Lemon balm, L-tryptophan and L-theanine. Traditional or mechanistic reasons to include them, thin trial evidence on their own, and a 2024 placebo-controlled blend trial that found no benefit beyond placebo (PMID: 38580720). Fine as supporting ingredients at stated amounts; not a reason to buy a product by themselves.

Compared: studied amount, what was found, who it suits, and price per night

Supplement Amount the trials used What was found Who it suits Veluna product, price per night
Low-dose melatonin 0.3 mg to 5 mg, 30 to 60 minutes before bed Modest, consistent; strongest for timing Jet lag, a late body clock, occasional nights Sleep Strips, 1 mg per dissolvable strip, $45 for 30 strips: $1.50 a night, $1.28 on subscription
Melatonin with botanicals 2 mg melatonin with valerian, chamomile, passionflower, lemon balm Herbs at supporting amounts around a low melatonin dose; the blend itself has not been tested in a trial A nightly capsule with every amount stated Sleep Formula, 2 capsules, $52 for 30 nights: $1.73 a night, $1.47 on subscription
Magnesium glycinate About 500 mg of magnesium a day in the older-adult trials Seventeen minutes sooner to sleep on average, low-quality evidence Anyone who wants no hormone in the routine Magnesium Glycinate, 275 mg elemental magnesium per 3 capsules, $52 for 30 nights: $1.73 a night, $1.47 on subscription
Ashwagandha 300 to 600 mg of root extract a day in most trials Studied mainly for stress; sleep findings secondary (see our ashwagandha guide) A busy mind at bedtime Organic Ashwagandha, 650 mg per capsule, $39 for 60 capsules: $1.30 a night at two a day, $1.11 on subscription
Valerian root 400 to 900 mg of extract Subjective improvement, no objective change Someone who wants a herb-only product and accepts mixed evidence Included in Sleep Formula at 150 mg; no single-ingredient Veluna product
Chamomile About 540 mg of extract a day Better sleep-quality scores in pooled trials Mild support, tea as a ritual Included in Sleep Formula at 100 mg

Prices are the one-time prices on the product pages on 13 October 2026; subscription prices are 15 percent lower. Every Veluna label states each amount individually, every product is third-party tested, and every set carries a 30-night money-back guarantee. The full label is on each product page.

How we ranked them

  • Trial evidence first. Placebo-controlled trials and pooled analyses, cited by PubMed ID in the table below, outrank tradition and testimonials.
  • The amount on the label against the amount in the trials. A product that cannot be compared with the studied amount, because it hides amounts in a proprietary blend, is ruled out.
  • Melatonin kept low. Our NIH label count shows most products sell far more melatonin than the research used; low amounts rank above high ones here.
  • Third-party testing and a full label. Testing is the only way to know the capsule matches the label.
  • Price per night, at the serving the label states, so a cheap bottle with a four-capsule serving does not look cheap.

Search for the best natural sleep aid and you get listicles that rank herbs by reputation, brand pages that rank them by what they sell, and forum threads that rank them by one person's week. None of that tells you how to read a label. This guide takes the other route: what the controlled trials of each ingredient actually used and found, how single-ingredient products compare with blends, how blends that include melatonin compare with those that leave it out, how capsules compare with gummies and tea, and the checklist we would use to judge any herbal sleep product, including our own.

What is the best herbal sleep aid?

There is no single best herbal sleep aid. Valerian has the most trials and the least consistent results, passionflower raised total sleep time in one two-week trial, chamomile improved a sleep-quality score in pooled trials, and melatonin, which is not a herb, has the largest evidence base with modest average effects. Pick by label amounts, not by reputation.

What the trials used and found, ingredient by ingredient

The table lists the sleep ingredients most often found in natural sleep aids, the amounts and durations the better trials used, what they reported, and the safety notes from the National Center for Complementary and Integrative Health (NCCIH) and the NIH Office of Dietary Supplements (ODS). Amounts are per day unless stated.

Ingredient What trials used What was found Safety notes
Valerian root Aqueous extracts of 400 to 900 mg, or 600 mg of a standardised dried-root extract, for a single night up to 28 days (NIH ODS). A 2020 meta-analysis of 60 studies (6,894 people) found subjective sleep quality improved across 10 pooled studies, attributed inconsistent results to variable extract quality, and recorded no severe adverse events in people aged 7 to 80 (PMID: 33086877). A 2024 umbrella review of 8 systematic reviews found a good safety profile and subjective improvements but no effect on objective measures (PMID: 38359657). An 18-trial meta-analysis found time to fall asleep changed by less than a minute versus placebo (PMID: 20347389). Used with apparent safety at 300 to 600 mg a day for up to 6 weeks; long-term safety unknown; headache, stomach upset, vivid dreams reported; not with alcohol or sedatives; little known in pregnancy or breastfeeding (NCCIH). ODS lists melatonin, kava and St. John's wort among supplements with possible additive sedative effects.
Chamomile 270 mg of a standardised extract twice daily for 28 days in the best-known trial (PMID: 21939549); teas and extracts of varying strength elsewhere. A 2024 meta-analysis of 10 trials (772 people) found a sleep-quality score improved by 1.88 points, awakenings improved in two of three studies, and sleep length, efficiency and daytime function did not change (PMID: 39106912). The 34-person extract trial found no significant diary differences versus placebo. Likely safe in food amounts; allergic reactions more likely with ragweed, chrysanthemum, marigold or daisy allergy; reported interactions with warfarin and some liver-metabolised drugs; theoretical interaction with sedatives (NCCIH).
Passionflower A standardised extract for 2 weeks in 110 adults (PMID: 31714321); one cup of tea nightly for a week in 41 adults (PMID: 21294203). Total sleep time on polysomnography rose by about 23 minutes versus placebo over 2 weeks; sleep efficiency and time awake improved within the passionflower group but not versus placebo. The tea trial found better subjective sleep quality versus placebo tea. Tea may be safe for up to 7 nights and extract for up to 8 weeks; drowsiness, dizziness and confusion possible; may slow the nervous system with anaesthesia, so stop before surgery; not in pregnancy (NCCIH).
Lemon balm A standardised phytosome extract in a placebo-controlled crossover trial (PMID: 39683592); a valerian and lemon balm combination in 100 women aged 50 to 60 (PMID: 24199972). A sleep-difficulty score averaged 6.8 on the extract versus 9.7 on placebo; several authors held positions at the extract's manufacturer. The combination trial reported a better sleep-quality score than placebo. No NCCIH fact sheet. Trials are small and recent; treat the evidence as preliminary.
Lavender (oral) Oral lavender oil capsules in trials aimed at anxiety rather than sleep. NCCIH judges it unclear whether lavender helps sleep quality; oral lavender has small studies for anxiety with limitations including a lack of independent funding (NCCIH). Oral products may be safe short term; diarrhoea, headache, nausea possible; theoretical interaction with sedatives (NCCIH).
GABA Oral natural or fermented GABA across 14 placebo-controlled studies. A 2020 systematic review found limited evidence for stress and very limited evidence for sleep (PMID: 33041752). No NCCIH fact sheet. Evidence base is small.
L-tryptophan Daily doses below and above 1 g. A meta-analysis found time awake after sleep onset shortened, more so at 1 g or above than below it, with no effect on other sleep components (PMID: 33942088). No NCCIH fact sheet. The effective amounts in trials are far above what most capsule blends contain.
Melatonin (a hormone, not a herb) 0.15 mg to 12 mg across 37 placebo-controlled trials, most lasting 4 weeks or less (PMID: 31722088). Across 17 studies, time to fall asleep shortened by an average of four minutes and sleep lengthened by about thirteen minutes versus placebo (PMID: 15649737); a 2024 dose-response meta-analysis of 26 trials found effects peaking at 4 mg a day (PMID: 38888087). Short-term use appears safe for most people, long-term data lacking; daytime sleepiness most common adverse event; not studied in pregnancy; medical supervision for epilepsy and blood thinners; may stay active longer in older adults (NCCIH).
Magnesium Various forms and elemental doses; 3 trials in 151 older adults pooled (PMID: 33865376); 12 trials in a 2026 review (PMID: 42661485). Time to fall asleep was 17 minutes shorter than placebo in the older-adult pooled analysis, rated low to very low quality; the 2026 review found inconsistent results and low certainty, with possible modest benefits for some subjective outcomes. Supplemental upper limit 350 mg a day for adults; can interact with some antibiotics and bisphosphonates; diarrhoea at high doses (NIH ODS).
Ashwagandha Standardised root extracts, 5 trials in 400 adults, with larger effects at 600 mg a day or more and 8 weeks or longer (PMID: 34559859). A small but significant effect on overall sleep; no serious side effects reported; long-term safety data limited. May be safe up to 3 months; rare cases of liver injury; avoid in pregnancy and breastfeeding, before surgery, and with autoimmune or thyroid conditions; possible interactions with diabetes, blood pressure, immunosuppressant, sedative, anticonvulsant and thyroid medicines (NCCIH).

Research discussed here relates to individual ingredients and does not establish that the finished Veluna product has been clinically studied or will produce the same results.

Two patterns run through the table. First, the positive findings are mostly subjective, small and short, and for valerian the 2017 American Academy of Sleep Medicine guideline recommended against its use for chronic insomnia in adults (NCCIH). Second, the amounts that produced those findings are specific: 400 to 900 mg of valerian extract, 540 mg a day of chamomile extract, 1 g or more of tryptophan. Those numbers are the yardstick for reading a label.

Single-ingredient products vs multi-ingredient blends

A single-ingredient product lets you match the trial amount and learn whether that one herb does anything for you. A blend offers several mechanisms in one capsule, which is appealing, but it comes with two honest caveats.

The first is that blends are rarely tested as blends, and when they are the results are mixed. A 2024 randomised placebo-controlled trial gave 64 adults with impaired sleep a combination of L-theanine, lemon balm, valerian and saffron for 6 weeks and measured sleep with actigraphy; the combination did not improve objective or subjective sleep more than placebo (PMID: 38580720). A valerian-hops combination did better: in 184 adults over 28 days it produced modest improvements in subjective sleep, few of which reached significance against placebo, with no residual effects and no rebound on stopping (PMID: 16335333), and a 2025 feasibility trial of the same type of combination in 40 people found tracker-measured sleep duration increased by about 22 minutes a night versus placebo (PMID: 40462685). The valerian meta-analysis also suggested benefits could be optimised with appropriate herbal partners (PMID: 33086877).

The second caveat is arithmetic. A capsule holds a fixed amount of material, so a seven-ingredient blend necessarily contains less of each ingredient than a single-ingredient product can. That is not a flaw if the label tells you the amounts; it is a problem when the amounts are hidden.

Blends that include melatonin vs herb-only blends

Blends that include melatonin Herb-only blends
What the main ingredient does Melatonin is a timing signal. NCCIH says supplements may help with jet lag and a delayed sleep-wake phase; pooled effects on falling asleep and sleep length are modest. Valerian, passionflower, chamomile and lemon balm are traditionally used to support a calm transition to sleep; the trial evidence is mostly subjective.
Size of the evidence Largest: 37 placebo-controlled trials in the adverse-event review alone (PMID: 31722088). Smaller and more variable; valerian has the most trials, with inconsistent results.
Who should avoid it Melatonin products are labelled not for pregnancy, nursing or anyone under 18; NCCIH advises medical supervision for people with epilepsy and those on blood thinners, and the 2015 AASM guideline recommends against melatonin in people with dementia. Depends on the herb: passionflower not in pregnancy or near surgery, chamomile with ragweed allergy or warfarin, valerian not with alcohol or sedatives (NCCIH).
Next-day effects Daytime sleepiness was the most frequently reported adverse event across trials, at under 2 percent of participants; melatonin may stay active longer in older adults (NCCIH). Morning sleepiness was noted at 900 mg of valerian but not at 600 mg in the ODS review of trials.
How long it has been used in trials Most trials 4 weeks or less; long-term safety information lacking (NCCIH). Valerian up to 6 weeks and passionflower extract up to 8 weeks with apparent safety; long-term use unknown (NCCIH).
Label check Total melatonin per serving and per unit; count every other melatonin source you use. Each herb's amount against the trial amounts in the table above.

Capsule vs gummy vs tea

  • Capsules state exact milligrams, carry no sugar, and can hold six or seven ingredients in one serving. The amount of each ingredient is limited by capsule size, so compare every line with the trial amounts.
  • Gummies add sugar or sugar alcohols and are the format most often involved in accidental ingestion by young children (NCCIH). For melatonin gummies specifically, a 2023 analysis found 22 of 25 products inaccurately labelled, with melatonin ranging from 74 to 347 percent of the labelled amount (NCCIH, summarising PMID: 37097362).
  • Teas are how passionflower and chamomile were taken in two of the trials above, and the dose per cup is unknowable from the box. A tea is a ritual as much as a dose, which is a fair reason to choose it, but it cannot be compared with an extract milligram for milligram.

How to judge a blend: the checklist

  • Every amount stated, or a proprietary blend? FDA labelling rules let a product group ingredients as a "Proprietary Blend" that lists only the total weight of the blend and its ingredients in descending order of weight, without the amount of each one (FDA Dietary Supplement Labeling Guide). A proprietary blend cannot be compared with the trial amounts, so it should be the first thing that rules a product out.
  • Total melatonin, per serving and per unit. If a blend includes melatonin, know the number before you take it, and do not add a gummy, strip or tart cherry product on the same night.
  • Each herb against its trial amount. Use the table: 400 to 900 mg of valerian extract, 540 mg a day of chamomile extract, 1 g or more of tryptophan. A blend may contain far less of each; that is a fact to know, not necessarily a reason to reject it, since blends are rarely tested at any amount.
  • Which part of the plant and which extract. ODS notes there is no scientific agreement on valerian's active constituents and that the composition of supplements can vary considerably between lots; the 2020 meta-analysis blamed inconsistent results on extract quality. NCCIH adds that the word "standardized" does not by itself guarantee quality or consistency.
  • Third-party testing of the finished product. Testing is the only way to know the capsule matches the label.
  • Interactions and who should avoid it. Valerian with alcohol or sedatives, chamomile with warfarin, passionflower near surgery, ashwagandha with thyroid or immunosuppressant medicines, melatonin with blood thinners or epilepsy: the NCCIH fact sheets list them, and anyone taking medication should talk to their doctor first.
  • Nightly or occasional. Trials ran from one night to 8 weeks; NCCIH gives valerian up to 6 weeks and passionflower extract up to 8 weeks with apparent safety and says long-term safety is unknown. Match the product's label to the pattern you intend.
  • Give it a trial's length before judging. The valerian trials that found effects over 28 days found the difference between valerian and placebo growing between day 14 and day 28 (NIH ODS). Individual responses vary, so hold the same product at the same time for a few weeks and keep a simple diary.

Where Veluna fits

We make one herbal blend for nightly use. Veluna Sleep Formula, a valerian root sleep supplement with 2 mg melatonin, is a botanical evening blend of valerian, chamomile, passionflower, lemon balm, GABA and L-tryptophan with a deliberately low 2 mg dose of melatonin to support your natural sleep-wake signal. Per two capsules: valerian extract 150 mg, chamomile extract 100 mg, GABA 100 mg, L-tryptophan 100 mg, lemon balm extract 100 mg, passionflower extract 100 mg and melatonin 2 mg; 60 capsules, 30 nights. Take two capsules with water 30 to 60 minutes before bed, as part of the same wind-down every night. It is non-GMO, third-party tested and made in an FDA-registered, GMP-compliant facility by our manufacturing partner.

Alongside Sleep Formula, Veluna makes three single-ingredient options that appear in the table above: Magnesium Glycinate (275 mg elemental magnesium per serving), Sleep Strips (1 mg melatonin per dissolvable strip, for occasional nights) and Organic Ashwagandha (650 mg per capsule). All four state every amount, are third-party tested and carry a 30-night money-back guarantee.

Read it against the checklist. Every amount is stated individually; there is no proprietary blend. It is built as a blend around 2 mg of melatonin, the dose the 2024 meta-analysis describes as the schedule most used in clinical practice, with the herbs at supporting amounts rather than the larger single-herb amounts used when valerian, chamomile or tryptophan were tested on their own (those amounts are in the table above). The finished product has not been tested in a trial. The herbs are traditionally used to support a calm transition to sleep; that is the extent of the claim.

It suits someone who wants a nightly capsule, a low melatonin dose and every amount on the label. It is not for anyone pregnant or nursing, anyone under 18, or anyone already using another melatonin product, and anyone taking medication or with a medical condition should talk to a doctor first. If you would rather leave melatonin out altogether, our magnesium glycinate and organic ashwagandha are single-ingredient products listed on the sleep supplements page.

Common questions

What is the strongest natural sleep aid?

No trial ranks them against each other, and "strongest" is not something the pooled numbers can settle. Melatonin has the largest evidence base, with effects that are consistent but modest: 4 minutes sooner to sleep and about 13 minutes more sleep across 17 studies (PMID: 15649737). Valerian is the most studied herb and the least consistent (PMID: 38359657). Magnesium shortened time to fall asleep by an average of seventeen minutes in older adults across three small trials rated low quality (PMID: 33865376). If strength is your criterion, the honest answer is that none of these is strong, and the ones that are strong are prescription medicines.

Is valerian or melatonin better for sleep?

They do different jobs. Melatonin is a timing signal with the larger evidence base; valerian is a sedative herb with inconsistent trial results and a good safety record (PMID: 33086877). ODS lists melatonin among the supplements that may have additive sedative effects with valerian, which is a reason to use one product that contains both at a stated dose rather than stacking two.

Are herbal sleep aids safe to take every night?

The trials are short. NCCIH reports valerian used with apparent safety at 300 to 600 mg a day for up to 6 weeks and passionflower extract for up to 8 weeks, and says long-term safety is unknown for both; for melatonin, short-term use appears safe for most people and long-term information is lacking. A product labelled for nightly use is still worth reviewing with your doctor if you find yourself using it for months.

Can I take a natural sleep aid with my medication?

Ask first. NCCIH and ODS list specific concerns: valerian with sedatives and alcohol, chamomile with warfarin and some liver-metabolised drugs, passionflower with anaesthesia, ashwagandha with thyroid, diabetes, blood pressure, immunosuppressant and sedative medicines, and melatonin for people with epilepsy or on blood thinners. "Natural" does not mean free of interactions.

How long does a herbal sleep aid take to work?

The trials give two kinds of answer and individual responses vary. Single-night valerian studies measured a change the same night, while the 28-day trials found the gap between valerian and placebo widening from day 14 to day 28 (NIH ODS). The passionflower polysomnography trial ran 2 weeks, the chamomile extract trial 28 days, and the lemon balm crossover and the four-ingredient blend trial 6 weeks. A few weeks at the same dose and time is a fair test; a single night is not.

Should I avoid products with a proprietary blend?

We would. The FDA rule requires only the blend's total weight and the order of its ingredients, so a "sleep blend 450 mg" could be mostly one cheap herb and a trace of everything else. A label that states each amount lets you compare it with the trials; a proprietary blend does not.

Is a gummy or a capsule better for a herbal sleep aid?

Capsules give exact amounts without sugar. Gummies add sugar or sugar alcohols, are more likely to end up in a child's hands (NCCIH), and in the one format audit that exists for melatonin, 22 of 25 gummy products did not match their labels (PMID: 37097362). If the only product you will actually take is a gummy, buy one that is third-party tested and keep it locked away.

References

  1. Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders: a systematic review and meta-analysis. J Evid Based Integr Med. 2020;25:2515690X20967323. PMID: 33086877
  2. Valente V, Machado D, Jorge S, Drake CL, Marques DR. Does valerian work for insomnia? An umbrella review of the evidence. Eur Neuropsychopharmacol. 2024. doi:10.1016/j.euroneuro.2024.01.008. PMID: 38359657
  3. Taibi DM, Landis CA, Petry H, Vitiello MV. A systematic review of valerian as a sleep aid: safe but not effective. Sleep Med Rev. 2007;11(3):209-230. PMID: 17517355
  4. Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, Sancho-Gómez P, Calbó-Caldentey C, Flores-Mateo G. Effectiveness of valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 2010;11(6):505-511. PMID: 20347389
  5. Kazemi A, Shojaei-Zarghani S, Eskandarzadeh P, Hashempur MH. Effects of chamomile (Matricaria chamomilla L.) on sleep: a systematic review and meta-analysis of clinical trials. Complement Ther Med. 2024;84:103071. PMID: 39106912
  6. Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78. PMID: 21939549
  7. Lee J, Jung HY, Lee SI, Choi JH, Kim SG. Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. Int Clin Psychopharmacol. 2020;35(1):29-35. PMID: 31714321
  8. Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011;25(8):1153-1159. PMID: 21294203
  9. Di Pierro F, Sisti D, Rocchi M, et al. Effects of Melissa officinalis phytosome on sleep quality: results of a prospective, double-blind, placebo-controlled, and cross-over study. Nutrients. 2024;16(23):4199. PMID: 39683592
  10. Taavoni S, Nazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopause. Complement Ther Clin Pract. 2013;19(4):193-196. PMID: 24199972
  11. Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80(2):306-316. PMID: 33942088
  12. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review. Front Neurosci. 2020;14:923. PMID: 33041752
  13. Gutiérrez-Romero SA, Torres-Narváez ES, Zamora-Gómez AC, et al. Effect of a nutraceutical combination on sleep quality among people with impaired sleep: a randomised, placebo-controlled trial. Sci Rep. 2024;14(1):8062. PMID: 38580720
  14. Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28(11):1465-1471. PMID: 16335333
  15. Schicktanz N, Gerhards C, Schlitt T, et al. Effects of a valerian-hops extract combination (Ze 91019) on sleep duration and daytime cognitive and psychological parameters in occasional insomnia: a randomized controlled feasibility trial. Brain Behav. 2025;15(6):e70600. PMID: 40462685
  16. Brzezinski A, Vangel MG, Wurtman RJ, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005;9(1):41-50. PMID: 15649737
  17. Cruz-Sanabria F, Bruno S, Crippa A, et al. Optimizing the time and dose of melatonin as a sleep-promoting drug: a systematic review of randomized controlled trials and dose-response meta-analysis. J Pineal Res. 2024;76(5):e12985. PMID: 38888087
  18. Besag FMC, Vasey MJ, Lao KSJ, Wong ICK. Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs. 2019;33(12):1167-1186. PMID: 31722088
  19. Cohen PA, Avula B, Wang YH, Katragunta K, Khan I. Quantity of melatonin and CBD in melatonin gummies sold in the US. JAMA. 2023;329(16):1401-1402. PMID: 37097362
  20. Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a systematic review and meta-analysis. BMC Complement Med Ther. 2021;21(1):125. PMID: 33865376
  21. Lopresti AL, Smith SJ, Drummond PD. Magnesium supplementation for sleep in adults: a systematic review of randomized controlled trials. J Diet Suppl. 2026;23(5):553-581. PMID: 42661485
  22. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. PMID: 34559859
  23. National Center for Complementary and Integrative Health. Valerian. nccih.nih.gov
  24. National Center for Complementary and Integrative Health. Chamomile. nccih.nih.gov
  25. National Center for Complementary and Integrative Health. Passionflower. nccih.nih.gov
  26. National Center for Complementary and Integrative Health. Lavender. nccih.nih.gov
  27. National Center for Complementary and Integrative Health. Ashwagandha. nccih.nih.gov
  28. National Center for Complementary and Integrative Health. Melatonin: What You Need To Know. nccih.nih.gov
  29. National Center for Complementary and Integrative Health. Using Dietary Supplements Wisely. nccih.nih.gov
  30. National Institutes of Health, Office of Dietary Supplements. Valerian: Fact Sheet for Health Professionals. ods.od.nih.gov
  31. National Institutes of Health, Office of Dietary Supplements. Magnesium: Fact Sheet for Health Professionals. ods.od.nih.gov
  32. U.S. Food and Drug Administration. Dietary Supplement Labeling Guide: Chapter IV. Nutrition Labeling. fda.gov

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is for informational purposes only and does not constitute medical advice. Talk to a healthcare professional before starting any supplement, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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Quality & manufacturing: Veluna products are made in FDA-registered, GMP-compliant manufacturing facilities. Every Veluna supplement is third-party tested and made in a third-party GMP-certified facility (NSF or UL), and Certificates of Analysis are available for every product on request. Every supplement lists its full Supplement Facts on its product page. Dietary supplements are not FDA approved.

Research linked here relates to individual ingredients and does not establish that the finished Veluna product has been clinically studied or will produce the same results.

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